HCID 67394150, compound → HCID 67392365, compound

HRID 908666Notes

Reaction equation

HRID 908666 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[O:12])=[N:8][C:7]=2[C:19]=1[N+:20]([O-])=O>[Pd].CO>[CH3:1][O:2][C:3]1[C:19]([NH2:20])=[C:7]2[N:8]=[C:9]([C:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)=[O:12])[S:10][C:6]2=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 67394150HCID 67394150, compound

Product 1

HCID 67392365HCID 67392365, compoundYield 90.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

20 mg of 10% palladium on activated carbon is added to 210 mg (0.65 mmol) of 5-methoxy-2-(morpholin-4-ylcarbonyl)-4-nitro-1,3-benzothiazole in solution in 10 ml of methanol. The reaction medium is then placed under stirring under a hydrogen atmosphere for 18 hours. The catalyst is then filtered out and the solvent evaporated off. 173 mg of the expected product (crude yield=91%) is obtained in the form of a yellow oil and is used in the following stage without other purification.

Workup

  1. filtrationThe catalyst is then filtered out
  2. customthe solvent evaporated off

Sources & evidence

ORD record
ord-79e0a37d5677432eb9f619830c2cb37d
Source dataset
uspto-grants-2011_09
Patent number
US08017637B2

Reaction notes

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