N,N-bis(3-aminopropyl)methylamine → HCID 67392430, compound

Participants

Reaction Conditions

Reaction Steps

51 μl (0.32 mmol; 0.5 equivalent) of N-(3-aminopropyl)-N-methylpropane-1,3-diamine is added to 200 mg (0.65 mmol) of 5-methoxy-2-(morpholin-4-ylcarbonyl)-1,3-benzothiazole-4,7-dione in solution in 15 ml of ethanol. The reaction mixture is maintained under stirring at 85° C. for 2 hours, then the solvent is evaporated off under reduced pressure and the expected product is purified by chromatography on a silica column (eluent: dichloromethane/methanol mixture 95/5) then recrystallized from a mixture of acetone and ethyl ether and 110 mg (yield=24%) of 5.5′-[(methylimino)bis(propane-3,1-diylimino)]bis[2-(morpholin-4-ylcarbonyl)-1,3-benzothiazole-4,7-dione] is obtained in the form of a red powder. Melting point=207-208° C.

Provenance & Evidence