HCID 67392406, compound → HCID 44476497, compound

Participants

Reaction Conditions

Reaction Steps

5-({3-[(3-aminopropyl)(methyl)amino]propyl}amino)-2-methyl-1,3-benzothiazole-4,7-dione is solubilized in 250 ml of ethanol and 2.12 g (6.16 mmol; 0.8 equivalent) of 5-methoxy-N-(4-methoxyphenyl)-4,7-dioxo-4,7-dihydro-1,3-benzothiazole-2-carboxamide is added. The reaction mixture is maintained under stirring at 60° C. for 4 hours, then the solvent is evaporated off under reduced pressure. The residue is then purified by chromatography on a silica column (eluent: dichloromethane/methanol: 95/5) and 450 mg (yield=9%) of N-(4-methoxyphenyl)-5-{[3-(methyl{3-[(2-methyl-4,7-dioxo-4,7-dihydro-1,3-benzothiazol-5-yl)amino]propyl}amino)propyl]amino}-4,7-dioxo-4,7-dihydro-1,3-benzothiazole-2-carboxamide is obtained in the form of red powder.

Provenance & Evidence