Triethylamine → 5-[(3-Bromopropyl)amino]-2-methyl-1,3-benzothiazole-4,7-dione

Participants

Reaction Conditions

Reaction Steps

1.57 g (7.17 mmol; 1.5 equivalent) of 3-bromopropylamine hydrobromide and 1.02 ml (7.17 mmol; 1.5 equivalent) of triethylamine are added to 1 g (4.78 mmol) of 5-methoxy-2-methyl-1,3-benzothiazole-4,7-dione in solution in 100 ml of methanol. The reaction mixture is maintained under stirring for 2 hours at 60° C., then the solvent is evaporated off under reduced pressure and the residue is purified by chromatography on a silica column (eluent: dichloromethane/methanol: 97/3). The 5-[(3-bromopropyl)amino]-2-methyl-1,3-benzothiazole-4,7-dione is obtained in the form of a red oil.

Provenance & Evidence