HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 908889Generated: October 26, 2026
t-Butyl bromide → Tert-butyl 4-cyano-5-(methylthio)thiophene-2-carboxylate
https://huagongshe.com/reaction/908889
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | t-Butyl bromide | HCID 10485 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Cyano-5-methylsulfanylthiophene-2-carboxylic acid | HCID 45594312 | — |
| Catalyst | Benzyltrimethylammonium chloride | HCID 5963 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | Tert-butyl 4-cyano-5-(methylthio)thiophene-2-carboxylate | HCID 66785900 | — |
Reaction Steps
A mixture of 4-cyano-5-(methylthio)thiophene-2-carboxylic acid (2.0 g, 10 mmol), benzyltrimethylammonium chloride (2.25 g, 10 mmol), tertbutyl bromide (54 mL, 480 mmol), and anhydrous potassium carbonate (36 g, 260 mmol) in dimethylacetamide (100 mL) was stirred at 60° C. for 6 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08017643B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-9d828ca4fbd949d3b9f207f6229b1d95 |
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| Source note | uspto-grants-2011_09 |
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