HCID 67401578, compound → HCID 67402265, compound

Participants

Reaction Steps

To a suspension containing 1-ethyl-2-(2-fluorophenyl)-5-nitro-1H-indole (0.78 g; 2.75 mmol) in 95° ethanol (100 ml) was added 10% Pd/C (0.1 g; 0.1 mmol) and the mixture underwent hydrogenation in a Parr hydrogenator (30 psi) for 4 hours. The mixture was filtered and the solution was evaporated under reduced pressure to give 1-ethyl-2-(2-fluorophenyl)-1H-indol-5-amine (0.8 g), which was used without any further purification.

Provenance & Evidence