HCID 23150774, compound → HCID 11978505, compound

Participants

Reaction Steps

A A suspension of 10% palladium on charcoal (25 mg) in a solution of trans-1-{3-[3-(4-benzyloxy-3-methoxyphenyl)allyloxy]propyl}piperidine (340 mg containing 28% wt dimethylsufoxide) in methanol (2.5 mL) is stirred overnight at room temperature under an atmosphere of dihydrogene. The suspension is filtered over a clarcel pad and the filtrate concentrated under reduced pressure. The product is dissolved in diethyl oxide and a solution of oxalic acid (61 mg) in acetone is added. The precipitate is filtered, washed with diethyl oxide and dried under vacuum to afford 150 mg of 1-{3-[3-(4-hydroxy-3-methoxyphenyl)propoxy]propyl}-piperidine, oxalate as a white solid melting at 110-111° C.

Provenance & Evidence