Potassium Hydroxide → HCID 23150774, compound

Participants

Reaction Steps

Following the procedure described in example 2, but starting from 3-(4-benzyloxy-3-methoxyphenyl)prop-2-en-1-ol (600 mg), potassium hydroxide (308 mg 85% wt) and 1-(3-chloropropyl)piperidine, hydrochloride (440 mg) in dimethylsufoxide (5 mL) affords 740 mg of trans-1-{3-[3-(4-benzyloxy-3-methoxyphenyl)-allyloxy]-propyl}piperidine containing 28% wt/wt DMSO used without any further purification. 3-(4-benzyloxy-3-methoxyphenyl)prop-2-en-1-ol can be prepared according to S. V. Reddy et al Chem. Lett. 32(11) 1038-9 (2003) or W. Gu et al Tetrahedron Lett. 41(32) 6079-82 (2000).

Provenance & Evidence