Potassium Hydroxide → HCID 11978617, compound

HRID 908905Notes

Reaction equation

HRID 908905 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8](/[CH:10]=[CH:11]/[CH2:12][OH:13])=[CH:9][C:4]=2[CH:3]=[CH:2]1.[OH-].[K+].Cl.Cl[CH2:18][CH2:19][CH2:20][N:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1.C([O-])(=O)C([O-])=O>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8](/[CH:10]=[CH:11]/[CH2:12][O:13][CH2:18][CH2:19][CH2:20][N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

5

Reactant 4

HCID 14797Potassium HydroxideHCID 71081OxalateHCID 115719161-(3-chloropropyl)pyrrolidine HydrochlorideHCID 14835733HCID 14835733, compound

Product 1

HCID 11978617HCID 11978617, compoundYield 12.2%

Procedure

A Following the procedure described in example 2, but starting from trans-3-(benzofuran-5-yl)prop-2-en-1-ol (600 mg), potassium hydroxide (477 mg 85% wt) and 1-(3-chloropropyl)pyrrolidine, hydrochloride (647 mg) in dimethylsufoxide (5 mL) affords 120 mg of trans-1-{3-[3-(benzofuran-5-yl)allyloxy]propyl}pyrrolidine, oxalate as a white solid.

Sources & evidence

ORD record
ord-d8c9edc87e144298b08be91be4010bff
Source dataset
uspto-grants-2011_09
Patent number
US08017646B2

Reaction notes

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