HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → 2-(Dimethylamino-4-phenylcyclohexylidene)-N-[2-(1H-indol-3-yl)ethyl]acetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(Dimethylamino-4-phenylcyclohexylidene)-N-[2-(1H-indol-3-yl)ethyl]acetamide | HCID 67386493 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(Dimethylamino-4-phenylcyclohexylidene)-N-[2-(1H-indol-3-yl)ethyl]acetamide hydrochloride | HCID 67386597 | 75% |
Reaction Steps
Chlorotrimethylsilane (0.034 ml, 0.26 mmol) was added to the solution of 2-(dimethylamino-4-phenylcyclohexylidene)-N-[2-(1H-indol-3-yl)ethyl]acetamide (75 mg, 0.178 mmol) in ethyl methyl ketone (15 ml). After 2 h it was possible to isolate the hydrochloride as a beige-coloured solid in a yield of 75% (61 mg) with an m.p. of 203-207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-11949c46d241454d9c9dcf307a1fef19 |
| Source note | uspto-grants-2011_09 |