Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[2-(1H-indol-3-yl)-1-methylethyl]acetamide hydrochloride

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Reaction Steps

Chlorotrimethylsilane (0.06 ml, 0.48 mmol) was added to a solution of the more polar diastereoisomer of 2-(4-dimethylamino-4-phenylcyclohexylidene)-N-[2-(1H-indol-3-yl)-1-methylethyl]acetamide (133 mg, 0.32 mmol) in ethyl methyl ketone (5 ml) and the mixture was stirred at RT for 1.5 h. The hydrochloride (Example 5) (66 mg, 46%) thereby precipitated out as a colourless solid with an m.p. of 182-186° C.

Provenance & Evidence