Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(3-phenyl-propyl)acetamide hydrochloride

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Reaction Steps

2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(3-phenyl-propyl)acetamide (203 mg, 0.536 mmol) was dissolved in ethyl methyl ketone (12 ml) with gentle heating and chlorotrimethylsilane (0.101 ml, 0.8 mmol) was added. After 2 h it was possible to isolate the product as a colourless solid in a yield of 95% (211 mg) with an m.p. of 225-230° C.

Provenance & Evidence