HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide | HCID 11538331 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide hydrochloride | HCID 11538330 | 52% |
Reaction Steps
2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide (266 mg, 0.755 mmol) was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.139 ml, 1.1 mmol) was added. After 2.5 h the hydrochloride was isolated as a colourless solid in a yield of 52% (152 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-78bb9bef1af44779ac8b2aa8182f185e |
| Source note | uspto-grants-2011_09 |