HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[3-(1H-indol-3-yl)propyl]acetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[3-(1H-indol-3-yl)propyl]acetamide | HCID 11655357 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[3-(1H-indol-3-yl)propyl]acetamide hydrochloride | HCID 11655356 | 75% |
Reaction Steps
2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[3-(1H-indol-3-yl)propyl]acetamide (742 mg, 1.78 mmol) was dissolved in ethyl methyl ketone (25 ml), and chlorotrimethylsilane (0.34 ml, 2.7 mmol) was added. After 2 h the hydrochloride was isolated as a beige-coloured solid with an m.p. of 165-173° C. in a yield of 75% (606 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-516b9981565a4fe4bea2f094ca775f56 |
| Source note | uspto-grants-2011_09 |