Chlorotrimethylsilane → HCID 11540046, compound

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Reaction Steps

The less polar diastereoisomer of 2-[4-dimethylamino-4-(4-fluorophenyl)cyclohexylidene]-N-[2-(1H-indol-3-yl)-1-methylethyl]acetamide (150 mg, 0.39 mmol) was dissolved in ethyl methyl ketone (10 ml), and chlorotrimethylsilane (0.075 ml, 0.59 mmol) was added. After 1.5 h it was possible to isolate the hydrochloride as a colourless solid in a yield of 63% (115 mg) with an m.p. of 188-191° C. (Example 21).

Provenance & Evidence