Chlorotrimethylsilane → HCID 11547019, compound

Participants

Reaction Steps

2-[4-Dimethylamino-4-(3-fluorophenyl)cyclohexylidene]-N-[2-(1H-indol-3-yl)ethyl]acetamide (350 mg, 0.82 mmol) was dissolved in ethyl methyl ketone (25 ml), and chlorotrimethylsilane (0.164 ml, 1.3 mmol) was added. After 1.5 h it was possible to isolate the hydrochloride as a colourless solid in a yield of 89% (336 mg) with an m.p. of 196-200° C.

Provenance & Evidence