Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[2-(1H-indol-3-yl)ethyl]acetamide hydrochloride

Participants

Reaction Steps

2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[2-(1H-indol-3-yl)ethyl]acetamide (141 mg, 0.35 mmol) was warmed gently in ethyl methyl ketone, and chlorotrimethylsilane (0.066 ml, 0.52 mmol) was added. After 1.5 h it was possible to filter off a beige-coloured, hygroscopic product with suction. The filtrate was reduced to a volume of 5 ml and ether was added. The hydrochloride thereby precipitated out as a colourless solid in a yield of 47% (72 mg). M.p.: 135-140° C.

Provenance & Evidence