Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexyl)-N-(1H-indol-3-ylmethyl)acetamide hydrochloride

Participants

Reaction Steps

2-(4-Dimethylamino-4-phenylcyclohexyl)-N-(1H-indol-3-ylmethyl)acetamide (213 mg, 0.54 mmol) was dissolved in ethyl methyl ketone with gentle heating and chlorotrimethylsilane (0.103 ml, 0.82 mmol) was added. After 1.5 h it was possible to obtain the hydrochloride as a colourless solid in a yield of 93% (214 mg) with an m.p. of 233-235° C.

Provenance & Evidence