Chlorotrimethylsilane → HCID 11511091, compound

Participants

Reaction Steps

2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[4-(1H-indol-3-yl)butyl]acetamide (58 mg, 0.142 mmol) was dissolved in ethyl methyl ketone with gentle heating and chlorotrimethylsilane (0.027 ml, 0.213 mmol) was added. After 1.5 h it was possible to obtain the hydrochloride as a colourless solid in a yield of 65% (43 mg) with an m.p. of 165-174° C.

Provenance & Evidence