反应详情

Palladium-on-charcoal (5%, 20 mg) was added to a solution of 2-(4-dimethylamino-4-phenyl-cyclohexylidene)-N-[3-(1H-indol-3-yl)propyl]-acetamide (base of Example 16; 305 mg, 0.734 mmol) in abs. methanol (30 ml). The reaction mixture was hydrogenated at RT under a pressure of 3 bar for 6 h. The catalyst was separated off over Celite and the filtrate was concentrated. After separation of the residue (289 mg) by chromatography on silica gel (20 g) with EA/methanol (2:1), the product was isolated as a beige-coloured oil in a yield of 29% (95 mg).

1. customThe catalyst was separated off over Celite
2. concentrationthe filtrate was concentrated
3. customAfter separation of the residue (289 mg) by chromatography on silica gel (20 g) with EA/methanol (2:1)
4. customthe product was isolated as a beige-coloured oil in a yield of 29% (95 mg)