反应详情

Palladium-on-charcoal (5%, 15 mg) was added to a solution of 2-(4-dimethylamino-4-phenylcyclohexylidene)-N-[5-(1H-indol-3-yl)pentyl]acetamide (base of Example 17; 246 mg, 0.55 mmol) in abs. methanol (30 ml). The reaction mixture was hydrogenated at RT under a pressure of 2 bar for 6 h. The catalyst was separated off over Celite and the filtrate was concentrated. After separation of the residue (234 mg) by chromatography on silica gel (30 g) with EA/methanol (1:1), the product was isolated as a beige-coloured oil in a yield of 46% (112 mg).

1. customThe catalyst was separated off over Celite
2. concentrationthe filtrate was concentrated
3. customAfter separation of the residue (234 mg) by chromatography on silica gel (30 g) with EA/methanol (1:1)
4. customthe product was isolated as a beige-coloured oil in a yield of 46% (112 mg)