HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[5-(1H-indol-3-yl)pentyl]-acetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[5-(1H-indol-3-yl)pentyl]-acetamide | HCID 11591127 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[5-(1H-indol-3-yl)pentyl]-acetamide hydrochloride | HCID 11591126 | 90% |
Reaction Steps
2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[5-(1H-indol-3-yl)pentyl]-acetamide (112 mg, 0.25 mmol) was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.048 ml, 0.38 mmol) was added. After 1 h ether (15 ml) was added to the reaction mixture. The product was obtained as a pink-coloured solid in a yield of 90% (108 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-27c6fd51e62a42f0913fe3c496006162 |
| Source note | uspto-grants-2011_09 |