Hydrochloric Acid → HCID 11510765, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl methyl ketone (55 ml) was added to a mixture of 2-(4-dimethylamino-4-phenylcyclohexyl)-N-[2-(1H-indol-3-yl)-1-methylethyl]acetamide with dicyclohexylurea (939 mg) and the mixture was heated to 40° C. and filtered. The acetamide thereby remained as a colourless solid (327 mg, 0.78 mmol) with an m.p. of 198-200° C. It was dissolved in ethanol (20 ml), and 5 M propanolic hydrochloric acid (0.22 ml, 1.11 mmol) was added. After 2 h the reaction mixture was concentrated to 2 ml, ether (50 ml) was added and the mixture was stirred at RT for 1 h. It was possible to isolate the product as a colourless solid with an m.p. of 150-155° C. in a yield of 33% (338 mg).

Provenance & Evidence