Hydrochloric Acid → HCID 11561089, compound

Participants

Reaction Steps

The more polar diastereoisomer of 2-[4-dimethylamino-4-(4-fluorophenyl)cyclohexyl]-N-(3-phenylpropyl)acetamide (295 mg, 0.74 mmol) was dissolved in a mixture of ethyl methyl ketone (10 ml) and ethanol (10 ml), 5 M propanolic hydrochloric acid (0.22 ml, 1.1 mmol) was added and the mixture was stirred at RT for 1.5 h. After addition of ether (50 ml), the mixture was stirred for 2 h and the hydrochloride which had precipitated out was separated off. The product was obtained in a yield of 67% (213 mg) (Example 43).

Provenance & Evidence