Hydrochloric Acid → HCID 11691094, compound

Participants

Reaction Steps

The more polar diastereoisomer of 2-[4-dimethylamino-4-(4-fluorophenyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide (224 mg, 0.74 mmol) was dissolved in a mixture of ethyl methyl ketone (15 ml) and ethanol (15 ml), 5 M isopropanolic hydrochloric acid (0.16 ml, 0.795 mmol) was added and the mixture was stirred at RT for 2.5 h. The product was filtered off with suction and obtained in a yield of 75% (181 mg) with an m.p. of 252-255° C.

Provenance & Evidence