Chlorotrimethylsilane → HCID 11662171, compound

Participants

Reaction Steps

The less polar diastereoisomer of 2-(4-dimethylamino-4-pyridin-2-ylcyclohexyl)-N-[2-(1H-indol-3-yl)ethyl]acetamide (141 mg, 0.348 mmol) was dissolved in ethyl methyl ketone (6 ml), and chlorotrimethylsilane (0.126 ml, 1.0 mmol) was added. After a reaction time of 1 h, the hydrochloride was obtained as a beige-coloured solid in a yield of 84% (130 mg) with an m.p. of 150-153° C. (Example 47).

Provenance & Evidence