Chlorotrimethylsilane → HCID 11718620, compound

Participants

Reaction Steps

The less polar diastereoisomer of 2-(4-dimethylamino-4-pyridin-2-ylcyclohexyl)-N-(3-phenylpropyl)acetamide (400 mg, 1.05 mmol) was dissolved in ethyl methyl ketone (10 ml), and chlorotrimethylsilane (0.2 ml, 1.58 mmol) was added. After a reaction time of 2 h, the hydrochloride was obtained as a beige-coloured solid in a yield of 94% (411 mg) with an m.p. of 218-220° C.

Provenance & Evidence