Chlorotrimethylsilane → 2-[4-dimethylamino-4-(3-fluorophenyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide Hydrochloride

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Reaction Steps

Chlorotrimethylsilane (0.164 ml, 1.3 mmol) was added to a solution of the more polar diastereoisomer of 2-[4-dimethylamino-4-(3-fluorophenyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide (372 mg, 0.776 mmol) in ethyl methyl ketone (30 ml) and the mixture was stirred at RT for 1.5 h. The reaction mixture was concentrated to 10 ml, ether (60 ml) was added and the mixture was stirred at RT for 20 min. The hydrochloride was obtained as a colourless solid in a yield of 87% (348 mg) (Example 51).

Provenance & Evidence