Diethyl Ether → 2-[4-Dimethylamino-4-(3-fluorophenyl)cyclohexyl]-N-(3-phenylpropyl)-acetamide hydrochloride

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Reaction Steps

The less polar diastereoisomer of 2-[4-dimethylamino-4-(3-fluorophenyl)cyclohexyl]-N-(3-phenylpropyl)-acetamide (64.3 mg, 0.16 mmol) was dissolved in ethyl methyl ketone (10 ml), and chlorotrimethylsilane (0.03 ml, 0.24 mmol) was added. After 2 h ether (10 ml) was added to the reaction mixture and the mixture was stirred at RT for 30 min. The hydrochloride was isolated as a colourless, hygroscopic solid in a yield of 78% (54 mg) (Example 53).

Provenance & Evidence