Diethyl Ether → 2-[4-Dimethylamino-4-(3-fluorophenyl)cyclohexyl]-N-(3-phenylpropyl)-acetamide hydrochloride

Participants

Reaction Steps

Chlorotrimethylsilane (0.132 ml, 1.04 mmol) was added to a solution of the more polar diastereoisomer of 2-[4-dimethylamino-4-(3-fluorophenyl)cyclohexyl]-N-(3-phenylpropyl)-acetamide (274 mg, 0.69 mmol) in ethyl methyl ketone (20 ml) and the mixture was stirred at RT for 1 h. Ether (20 ml) was added to the reaction mixture and the mixture was stirred at RT for 1 h. The hydrochloride was obtained as a colourless solid in a yield of 82% (245.5 mg) with an m.p. of 205-207° C. (Example 54).

Provenance & Evidence