反应详情

Chlorotrimethylsilane (0.122 ml) and water (9 μl) were added to a solution of the more polar diastereoisomer of 2-(4-dimethylamino-4-phenyl-cyclohexyl)-N-(4-fluoro-phenyl)-acetamide (310 mg, 0.9 mmol) in ethyl methyl ketone (2 ml). After 18 h it was possible to isolate the hydrochloride as a solid in a yield of 64% (220 mg; 0.6 mmol) (Example 58).