Water → 2-(4-Dimethylamino-4-phenyl-cyclohexyl)-N-p-tolyl-acetamide hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Chlorotrimethylsilane	HCID 6397	—
Reactant	2-(4-Dimethylamino-4-phenyl-cyclohexyl)-N-p-tolyl-acetamide	HCID 11610744	—
Solvent	Methyl Ethyl Ketone	HCID 6569	—
Product	2-(4-Dimethylamino-4-phenyl-cyclohexyl)-N-p-tolyl-acetamide hydrochloride	HCID 11610743	—

Reaction Steps

Chlorotrimethylsilane (0.477 ml) and water (34 μl) were added to a solution of the more polar diastereoisomer of 2-(4-dimethylamino-4-phenyl-cyclohexyl)-N-p-tolyl-acetamide (1.2 g, 3.4 mmol) in ethyl methyl ketone (10 ml). The hydrochloride was extracted as an oil with hexane and isolated in a yield of 78% (1.04 g; 2.7 mmol) (Example 60).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08017630B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-e29ac0d6e54541a5aa239b608cc35678
Source note	uspto-grants-2011_09