Lithium hydroxide, monohydrate → HCID 51356968, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 52, rac-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-acetic acid ethyl ester (83 mg, 0.144 mmol, example C16) was reacted with lithium hydroxide hydrate (36 mg, 0.945 mmol, Aldrich) to give rac-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-acetic acid (71 mg, 92%) HRMS (ES+) m/z Calcd for C25H25Cl2F2N3O3+H [(M+H)+]: 524.1314; Found: 524.1315.

Provenance & Evidence