Lithium hydroxide, monohydrate → HCID 51357253, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 8, rac-3-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-propionic acid ethyl ester (99 mg, 0.175 mmol, example 72) was reacted with lithium hydroxide hydrate (44 mg, 1.047 mmol, Aldrich) to give rac-3-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-propionic acid (94 mg, 99%). HRMS (ES+) m/z Calcd for C26H27Cl2F2N3O3+H [(M+H)+]: 538.1471; Found: 538.1470.

Provenance & Evidence