Methylamine → HCID 75631835, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 59, a mixture of rac-3-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]-amino}-propionic acid (24 mg, 0.0446 mmole, example 73) was reacted with a solution of methylamine (0.05 mL, 2M in THF, 0.10 mmol, Aldrich) to give rac-(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carboxylic acid (2-methylcarbamoyl-ethyl)-amide (17.2 mg, 70%) as a white solid. HRMS (ES+) m/z Calcd for C27H30Cl2F2N4O2+H [(M+H)+]: 551.1787; Found: 551.1789.

Provenance & Evidence