HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178456374, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Isopropylpiperazine | HCID 78013 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178453972 | HCID 178453972 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178456374 | HCID 178456374 | 107.5% |
Reaction Steps
A mixture of 3 g (12 mmol) 4-tert-butoxycarbonylamino-trans-cyclohexane carboxylic acid (commercially available), 1.74 g (14 mmol) 1-(2-propyl)-piperazine (commercially available), 4.75 g (15 mmol) TBTU and 3.64 g (36 mmol) NEt3 in 10 ml DMF was stirred for 3 h at room temperature. After evaporation the residue was washed with 1N NaHCO3 solution, extracted with DCM and the combined organic layers dried with MgSO4 and evaporated to dryness to yield 4.56 g (94%) of the title compound. MS (m/e): 354.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017773B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-5469706f48e744b9b5c9bce029331afc |
| Source note | uspto-grants-2011_09 |