Lithium Hydroxide → HCID 67394149, compound

Participants

Reaction Steps

A mixture of 1.9 g (4.7 mmol) trans-4-(4-cyano-benzenesulfonylamino)-cyclohexanecarboxylic acid benzyl ester and 0.8 g (1.9 mmol) LiOH in a mixture of methanol, THF and water was stirred at room temperature for 2 h. The mixture was evaporated to dryness and 10 mL DMF, 0.7 g (8.1 mmol) piperazine, 2.87 g (8.9 mmol) TBTU and 2.26 g (22 mmol) NEt3 was added. The mixture was stirred at room temperature for 1 h and evaporated to dryness. The residue was purified by column chromatography on silica obtaining 0.3 g (16%) of the title compound. MS (m/e): 377.1 (MH+).

Provenance & Evidence