HCID 57850477, compound → HCID 53373728, compound

HRID 909269Notes

Reaction equation

[Br:1][C:2]1[C:3]([S:11][C:12]2[NH:13][C:14]3[CH:19]=[CH:18][N:17]=[C:16]([NH2:20])[C:15]=3[N:21]=2)=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1.[C:22]([O:25][C@@H:26]([CH3:48])[C:27]([N:29]1[CH2:34][CH2:33][CH:32]([CH2:35][CH2:36]OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:31][CH2:30]1)=[O:28])(=[O:24])[CH3:23]>>[C:22]([O:25][C@@H:26]([CH3:48])[C:27]([N:29]1[CH2:34][CH2:33][CH:32]([CH2:35][CH2:36][N:13]2[C:14]3[CH:19]=[CH:18][N:17]=[C:16]([NH2:20])[C:15]=3[N:21]=[C:12]2[S:11][C:3]2[C:2]([Br:1])=[CH:10][C:6]3[O:7][CH2:8][O:9][C:5]=3[CH:4]=2)[CH2:31][CH2:30]1)=[O:28])(=[O:24])[CH3:23]

Participants

Reactant 2

HCID 57850477HCID 57850477, compound

HCID 67145169HCID 67145169, compound

Product 1

HCID 53373728HCID 53373728, compound

Procedure

The title compound was prepared by a similar procedure described for step 7 of example 1 using 2-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-1H-imidazo[4,5-c]pyridin-4-amine (350 mg, 0.95 mmol) and (2S)-1-[4-(2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)piperidin-1-yl]-1-oxopropan-2-yl acetate (662 mg, 1.66 mmol). LC-MS [M+H]+ 590.1. This product is used for the next step without further purification.

Workup

customThis product is used for the next step without further purification

Sources & evidence

ORD record: ord-991fa1cb7072489da2fba33483ae397f
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08017780B1

Reaction notes

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