Potassium Carbonate → HCID 53373729, compound

Participants

Reaction Steps

To a solution of (2S)-1-[4-(2-{4-amino-2-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-1H-imidazo[4,5-c]pyridin-1-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl acetate (300 mg, 0.50 mmol) in MeOH (5 mL) was added K2CO3 (140 mg, 0.01 mmol) and the resulting mixture was stirred for 6 h at room temperature. After the completion of reaction, solids were collected by filtration, washed with water and dried to give the title product. 1H NMR (DMSO-d6) δ; 7.71 (d, J=5.8 Hz, 1H), 7.37 (s, 1H), 6.79 (d, J=5.8 Hz, 1H), 6.67 (s, 1H), 6.39 (s, 2H), 6.07 (s, 2H), 5.30-5.40 (m, 1H), 4.15-4.3 (m, 3H), 3.74 (brd, J=13.2 Hz, 1H), 2.88-3.0 (m, 1H), 2.40-2.55 (m, 1H), 1.62-1.76 (m, 2H), 1.45-1.58 (m, 3H), 1.26 (t, J=8.2 Hz, 3H), 0.87-1.18 (m, 2H); TOF-MS [M+H]+ 550.0915.

Provenance & Evidence