HCID 57850477, compound → HCID 53389656, compound

HRID 909271Notes

Reaction equation

[CH3:1][N:2]([CH3:23])[C:3]1[C:4]([S:12][C:13]2[NH:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]([NH2:21])[C:16]=3[N:22]=2)=[CH:5][C:6]2[O:10][CH2:9][O:8][C:7]=2[CH:11]=1.[C:24]([O:27][C@@H:28]([CH3:50])[C:29]([N:31]1[CH2:36][CH2:35][CH:34]([CH2:37][CH2:38]OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:33][CH2:32]1)=[O:30])(=[O:26])[CH3:25]>>[C:24]([O:27][C@@H:28]([CH3:50])[C:29]([N:31]1[CH2:36][CH2:35][CH:34]([CH2:37][CH2:38][N:14]2[C:15]3[CH:20]=[CH:19][N:18]=[C:17]([NH2:21])[C:16]=3[N:22]=[C:13]2[S:12][C:4]2[C:3]([N:2]([CH3:23])[CH3:1])=[CH:11][C:7]3[O:8][CH2:9][O:10][C:6]=3[CH:5]=2)[CH2:33][CH2:32]1)=[O:30])(=[O:26])[CH3:25]

Participants

Reactant 2

HCID 57850477HCID 57850477, compound

HCID 67409434HCID 67409434, compound

Product 1

HCID 53389656HCID 53389656, compound

Procedure

The title compound was prepared by a similar procedure described for step 7 of example 1 using 2-{[6-(dimethylamino)-1,3-benzodioxol-5-yl]sulfanyl}-1H-imidazo[4,5-c]pyridin-4-amine (150 mg, 0.45 mmol) and (2S)-1-[4-(2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)piperidin-1-yl]-1-oxopropan-2-yl acetate (542 mg, 1.36 mmol). TOF LC-MS [M+H]+ 555.238.

Sources & evidence

ORD record: ord-b7473d5894494e799c2ec83c827aabe7
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08017780B1

Reaction notes

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