化工社化工社 化学情報印刷レポート · 研究参考用
HRID 909377作成日：2026年10月26日
3-Bromo-5-ethoxy-4-hydroxybenzaldehyde → 4-(3-Bromo-5-ethoxy-4-hydroxy-phenyl)-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile
https://huagongshe.com/reaction/909377
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Bromo-5-ethoxy-4-hydroxybenzaldehyde | HCID 612496 | — |
| 反応物 | 5-Propylcyclohexane-1,3-dione | HCID 2737224 | — |
| 反応物 | 3-Aminocrotonitrile | HCID 5324720 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(3-Bromo-5-ethoxy-4-hydroxy-phenyl)-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile | HCID 67023381 | — |
反応手順
A mixture of 3-bromo-5-ethoxy-4-hydroxy-benzaldehyde (6 g), 3-aminocrotonitrile (2.01 g) and 5-propylcyclohexane-1,3-dione (3.8 g) in ethanol (20 ml) was stirred at 80° C. for 4 h. The reaction mixture was concentrated in vacuo and the residue was chromatographed on silica gel in heptane/EtOAc=1/1 (v/v) as eluent. Yield: 6.3 g. MS-ESI: [M+H]+=445/447
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08017782B2 |
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| 出典データセット | uspto-grants-2011_09 |
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| ORD ID | ord-33af0e158e4142d89ab4d021d10fa4db |
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| 出典メモ | uspto-grants-2011_09 |
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