Triethylamine → HCID 67411229, compound

Participants

Reaction Steps

A mixture of the product of step b (117 mg), triethylamine (81 μl) and isobutyrylchloride (24 μl) in dichloromethane (3 ml) was stirred for 17 h. The mixture was diluted with dichloromethane and washed with 0.5N aqueous HCl. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was chromatographed on silicagel in heptane/EtOAc (from 1/0 to 0/1) as eluent. Yield: 69 mg. MS-ESI: [M+H]+=610.4/612.4; HPLC: Rt=19.45 min. (method 1). Diast. ratio: 5:1

Provenance & Evidence