HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-hydroxybenzaldehyde → 4-(3-Bromo-4-hydroxy-phenyl)-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-hydroxybenzaldehyde | HCID 76308 | — |
| Reactant | 5-Propylcyclohexane-1,3-dione | HCID 2737224 | — |
| Reactant | 3-Aminocrotonitrile | HCID 5324720 | — |
| Product | 4-(3-Bromo-4-hydroxy-phenyl)-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile | HCID 67412261 | — |
Reaction Steps
The reaction of 3-bromo-4-hydroxy-benzaldehyde (13.07 g) with 3-aminocrotonitril (5.34 g) and 5-propylcyclohexane-1,3-dione (10.02 g) was performed according to the method described in example 1a. Yield: 20.25 g. MS-ESI: [M+H]+=401/403
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017782B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-85b90a07053d47d69bbd7eeb014e16de |
| Source note | uspto-grants-2011_09 |