HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 67410110, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 4-[3-Bromo-5-isopropoxy-4-(4-nitro-benzyloxy)-phenyl]-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile | HCID 67413208 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67410110 | HCID 67410110 | — |
Reaction Steps
To a solution of the product isolated in step c (750 mg) and acetic acid (1.5 ml) in THF (50 ml) was added zinc dust (1.5 g) under vigorous stirring. The mixture was stirred for 2 h and then filtered. The mixture was diluted with EtOAc and washed with sat. aq. NaHCO3. The organic layer was dried (MgSO4), filtered and concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017782B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-09c347ce1ad143619084111af8d1777c |
| Source note | uspto-grants-2011_09 |