HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 909389Generated: November 3, 2026
Chlorosulfonic acid → 3-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid
https://huagongshe.com/reaction/909389
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | 3-Bromo-4-fluorobenzoic acid | HCID 70509 | — |
| Product | 3-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid | HCID 50998480 | — |
Reaction Steps
3-Bromo-4-fluoro-benzoic acid (2.0 g) was dissolved in chlorosulfonic acid (97%, 35 ml) and heated at 170° C. for 72 h. The reaction mixture was cooled to RT and added dropwise to an ice-water mixture. Extraction with EtOAc, drying (MgSO4) and concentration in vacuo gave the desired compound. Yield: 2.5 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08017782B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-c23664391d7b449785c805f2ed21d0e8 |
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| Source note | uspto-grants-2011_09 |
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