HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 3-Bromo-4-fluoro-5-(pyrrolidine-1-sulfonyl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid | HCID 50998480 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | 3-Bromo-4-fluoro-5-(pyrrolidine-1-sulfonyl)-benzoic acid | HCID 67412653 | — |
Reaction Steps
To a solution of 3-Bromo-5-chlorosulfonyl-4-fluoro-benzoic acid (3.0 g) in dioxane/water (9/1 (v/v), 30 ml) was added DiPEA (5 ml) and pyrrolidine (1.55 ml). After stirring for 2 h, the mixture was diluted with EtOAc and washed with 2 M aq. HCl. The organic layer was dried (Na2SO4) and concentrated in vacuo. Yield: 2.3 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017782B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-1739cdca679a4eb99b5f68c8de8e08d0 |
| Source note | uspto-grants-2011_09 |