HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → 3-Bromo-4-(2-methoxy-ethylamino)-5-(pyrrolidine-1-sulfonyl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 3-Bromo-4-fluoro-5-(pyrrolidine-1-sulfonyl)-benzoic acid | HCID 67412653 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 3-Bromo-4-(2-methoxy-ethylamino)-5-(pyrrolidine-1-sulfonyl)-benzoic acid | HCID 67410090 | — |
Reaction Steps
A solution of 3-Bromo-4-fluoro-5-(pyrrolidine-1-sulfonyl)-benzoic acid (500 mg) in 2-methoxy-ethylamine was heated at 80° C. for 3 h. The mixture was dissolved in 2 M aq. NaOH and washed with EtOAc. The aqueous layer was acidified with 2 M HCl and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated in vacuo. Yield: 543 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017782B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-c1f40565bac84f6584eb21939d099775 |
| Source note | uspto-grants-2011_09 |