Trifluoroacetic acid → HCID 59290424, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 3-(3-(2-methyl-2H-tetrazol-5-yl)phenethoxy)propanoate [Example 7, Step iii)] (500 mg), DCM (4 mL) and TFA (4 mL) was stirred at 25° C. for 30 min and concentrated under vacuum to give the subtitled compound as a gum (612 mg). 1H NMR (300 MHz, CDCl3) δ 8.05 (s, 1H), 7.93 (dt, J=7.8, 1.4 Hz, 1H), 7.41 (t, J=7.6 Hz, 1H), 7.31 (dt, J=1.4 and 7.7 Hz, 1H), 4.42 (s, 3H), 3.78 (t, J=5.9 Hz, 2H), 3.77 (t, J=6.3 Hz, 2H), 2.97 (t, J=6.3 Hz, 2H), 2.64 (t, J=6.1 Hz, 2H).

Provenance & Evidence