Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 909903Generated: October 30, 2026

Trifluoroacetic acid → HCID 59290395, compound

https://huagongshe.com/reaction/909903

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactanttert-butyl 3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanoateHCID 67076290—
SolventDichloromethaneHCID 6344—
ProductHCID 59290395HCID 59290395—

Reaction Conditions

Temperature25 °C

Reaction Steps

A mixture of tert-butyl 3-(3-(1-methyl-1H-tetrazol-5-yl)phenethoxy)propanoate [Example 7, Step iii)] (135 mg), DCM (4 mL) and TFA (4 mL) was stirred at 25° C. for 30 min and concentrated under vacuum to afford the subtitled compound as a gum. 1H NMR (400 MHz, CDCl3) δ 7.72 (s, 1H), 7.53-7.41 (m, 3H), 4.18 (s, 3H), 3.78-3.72 (m, 4H), 2.96 (t, J=5.9 Hz, 2H), 2.59 (t, J=5.9 Hz, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08017602B2
Source datasetuspto-grants-2011_09
ORD IDord-aed06114bcee4e438fe0d8733532afca
Source noteuspto-grants-2011_09