HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-(3-(1,2,4-Oxadiazol-3-yl)phenethoxy)-N-cyclohexyl-N-(2-oxoethyl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-(3-(1,2,4-Oxadiazol-3-yl)phenethoxy)-N-cyclohexyl-N-(2,2-dimethoxyethyl)propanamide | HCID 59290375 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 3-(3-(1,2,4-Oxadiazol-3-yl)phenethoxy)-N-cyclohexyl-N-(2-oxoethyl)propanamide | HCID 86641260 | — |
Reaction Steps
To 3-(3-(1,2,4-oxadiazol-3-yl)phenethoxy)-N-cyclohexyl-N-(2,2-dimethoxyethyl)propanamide [Example 11, Step ii)] (500 mg) in NMP (4 mL) was added p-toluenesulfonic acid (441 mg) and the mixture stirred for 8 h. After work-up the material was used in the next step directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017602B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-87d22aded8914e95a8b783841780ea93 |
| Source note | uspto-grants-2011_09 |